End Processing in NHEJ by Polymerase {lambda} and PNKP is coordinated during short-range synapsis
Alex Vogt, Andrea M. Kaminski, Jason G. Williams, Tasmin Naila, Danny Laurent, Alan E. Tomkinson, Susan P. Lees‐Miller, Lars Christian Pedersen, Thomas A. Kunkel, Yuan He
The paper determines the cryo-EM structure of Pol λ bound to the short-range synaptic complex, revealing its recruitment mechanism and coordinated activity with PNKP in NHEJ end processing.
Nature Communications · Sep 9, 2026Peer-reviewedBiophysics