Author

Susan P. Lees‐Miller

National Institutes of HealthORCID 0000-0001-5809-2516Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alan E. TomkinsoniD· 1 shared Alex VogtiD· 1 shared Andrea M. KaminskiiD· 1 shared Danny LaurentiD· 1 shared Ilya J. FinkelsteiniD· 1 shared Jason G. Williams· 1 shared Lars Christian PederseniD· 1 shared Linda LeeiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Alan E. TomkinsonORCID

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2 papers

Recent·Most cited

End Processing in NHEJ by Polymerase {lambda} and PNKP is coordinated during short-range synapsis

Alex Vogt, Andrea M. Kaminski, Jason G. Williams, Tasmin Naila, Danny Laurent, Alan E. Tomkinson, Susan P. Lees‐Miller, Lars Christian Pedersen, Thomas A. Kunkel, Yuan He

The paper determines the cryo-EM structure of Pol λ bound to the short-range synaptic complex, revealing its recruitment mechanism and coordinated activity with PNKP in NHEJ end processing.

Nature Communications · Sep 9, 2026Peer-reviewedBiophysics

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

Rajashree A. Deshpande, Logan R. Myler, Michael M. Soniat, Nodar Makharashvili, Linda Lee, Susan P. Lees‐Miller, Ilya J. Finkelstein, Tanya T. Paull

This study shows DNA-PK promotes MRN and phosphorylated CtIP for efficient DNA end processing, facilitating the transition from non-homologous end joining to homologous recombination.

Science Advances · Jan 8, 2020Peer-reviewedMolecular Biology