Engaging Unstabilized Alkyl Radicals with Pyridoxal Radical Biocatalysis: Enantiodivergent Synthesis of Aliphatic Non-Canonical Amino Acids
Lei Cheng, Jasper Chen, Zhiyu Bo, Xiangyu Zhang, Peng Liu, Yang Yang
This paper develops a biocatalytic method using engineered PLP enzymes to selectively synthesize L- and D-amino acids from alkyl radicals.
Journal of the American Chemical Society · Jan 30, 2026Peer-reviewedBiochemistry