Author

Zhiyu Bo

University of California, Santa BarbaraORCID 0009-0002-1463-2829Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1

Frequent Co-Authors

Lei ChengiD· 2 shared Peng LiuiD· 2 shared Yang YangiD· 2 shared Àmarjit Singh· 1 shared Jasper Chen· 1 shared Xiangyu ZhangiD· 1 shared Xiangyu ZhangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

Lei ChengORCID

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2 papers

Recent·Most cited

Photobiocatalytic Diastereo- and Enantioselective Synthesis of Non-Canonical Amino Acids Bearing Challenging Stereochemical Dyads and Triads

Zhiyu Bo, Lei Cheng, Xiangyu Zhang, Àmarjit Singh, Peng Liu, Yang Yang

This paper develops engineered PLP-dependent biocatalysts for stereodivergent synthesis of non-canonical amino acids with complex stereochemical arrays, achieving high stereoselectivity and yield.

bioRxiv · Oct 9, 2026 · PreprintBiochemistry

Engaging Unstabilized Alkyl Radicals with Pyridoxal Radical Biocatalysis: Enantiodivergent Synthesis of Aliphatic Non-Canonical Amino Acids

Lei Cheng, Jasper Chen, Zhiyu Bo, Xiangyu Zhang, Peng Liu, Yang Yang

This paper develops a biocatalytic method using engineered PLP enzymes to selectively synthesize L- and D-amino acids from alkyl radicals.

Journal of the American Chemical Society · Jan 30, 2026Peer-reviewedBiochemistry