DNA topological regulation by topoisomerase IIβ-DNA-PK interaction is important for controlled hypoxia-inducible gene expression
Heeyoun Bunch, Jihye Park, Jasper K. Solverson, Jeongho Lee, Ji-Seung Yoo, Huiming Lu, Jaeyeon Jang, Young-Ran Yoon, Jae‐Han Jeon, Matthew J. Schellenberg, Inuk Jung, Stuart K. Calderwood, Keunsoo Kang, Anthony J. Davis
The paper shows that TOP2B and DNA-PK regulate hypoxia-inducible gene expression through DNA topology changes, with DNA-PK phosphorylating TOP2B to control its activity.
bioRxiv · Jan 6, 2025 · PreprintMolecular Biology