Keunsoo Kang

BRAID calibrates RNA-seq splicing ΔPSI estimates using RT-PCR residuals to provide reliable 95% intervals, improving coverage and reducing false positives compared to existing methods.

This study identifies aberrant 3'UTR splicing that drives FUS-dependent mRNA condensates, sequesters β-catenin in the cytoplasm, and promotes cancer aggressiveness in colorectal cancer.

The paper identifies a functional regulatory circuit involving TOP2B, BARD1, and ERK2 in IEG transcription, showing how their interactions are modulated by ubiquitination and phosphorylation.

This study identifies JAK inhibitor-selective epigenetic regulation of IFN-γ signature genes in macrophages from RA and COVID-19 patients, revealing therapeutic insights and risks.

The paper shows that TOP2B and DNA-PK regulate hypoxia-inducible gene expression through DNA topology changes, with DNA-PK phosphorylating TOP2B to control its activity.

HiCAT improves immune cell subtype identification in single-cell RNA-seq by using a hierarchical marker-based approach, revealing new disease-related features in ulcerative colitis.

The paper generates a reference epigenome for domestic dogs using integrative sequencing across 11 tissues, enabling comparative studies and identifying tissue-specific epigenomic features.

This paper identifies a novel role for the BRCA1-BARD1 complex in regulating transcription by modulating topoisomerase IIβ stability and activity during gene activation.

This study investigates how arsenic hexoxide affects cell proliferation and gene expression differently in normal and cancerous human breast epithelial cells.

TraRECo improves de novo transcriptome assembly by using a greedy approach with error correction through consensus matrix construction, enhancing sensitivity and depth information quality.

Wx is a neural network-based feature selection algorithm that identifies optimal gene sets for distinguishing cancer from normal samples in NGS data, outperforming existing biomarker candidates.