Heeyoun Bunch

The paper identifies a functional regulatory circuit involving TOP2B, BARD1, and ERK2 in IEG transcription, showing how their interactions are modulated by ubiquitination and phosphorylation.

This study shows that Jerusalem artichoke extracts reduce FASN and ACACA expression, which are key enzymes in fatty acid biosynthesis, and links this effect to topoisomerase II activity.

This study identifies a novel DNA endonuclease activity of human ERK1, showing it can catalyze single-strand DNA breaks in a sequence-unspecific but topology-sensitive manner.

The paper shows that TOP2B and DNA-PK regulate hypoxia-inducible gene expression through DNA topology changes, with DNA-PK phosphorylating TOP2B to control its activity.

This study identifies ERK2's role in regulating TOP2B phosphorylation to facilitate transcriptional activation of immediate early genes.

This study shows that Lactiplantibacillus plantarum K8 lysates suppress hypoxia-induced gene expression by reducing HIF1 accumulation and its target genes.

This paper identifies a novel role for the BRCA1-BARD1 complex in regulating transcription by modulating topoisomerase IIβ stability and activity during gene activation.

This study investigates how arsenic hexoxide affects cell proliferation and gene expression differently in normal and cancerous human breast epithelial cells.