Cell BiologybioRxiv
Functionally redundant control of cardiac hypertrophic signaling by inositol 1,4,5-trisphosphate receptors
M. Iveth Garcia, Anja Karlstaedt, Javier Amione-Guerra…·Darren Boehning
This study shows all three IP3R isoforms are required for endothelin-1-induced hypertrophic signaling in cardiomyocytes, with IP3Rs mediating positive inotropic effects and NFAT activation.