RNA helicase DDX1 regulates germinal centre selection and affinity maturation by promoting tRNA ligase activity
Rachael Kimber, Sarah Ingelsfield, Michael Screen, Fiamma Salerno, Louise S. Matheson, Hanneke Okkenhaug, Alex J. Whale, Jayalini Assalaarachchi, Melanie Stammers, Deniz Akdeniz, Simon Andrews, Claudia Ribeiro de Almeida
This study shows DDX1 promotes B-cell proliferation in germinal centres by enhancing mRNA translation through tRNA ligase activity, crucial for affinity maturation.
bioRxiv · Jan 10, 2025 · PreprintImmunology