Alex J. Whale

This study identifies ZFP36L1 and ZFP36L2 as RNA-binding proteins that regulate the G2-M checkpoint in GC B cells to prevent replication stress and maintain genome stability.

TrAEL-seq is a method for profiling DNA replication dynamics in mammalian cells without requiring synchronization or drugs, showing replication fork speed and initiation zone effects.

This study shows DDX1 promotes B-cell proliferation in germinal centres by enhancing mRNA translation through tRNA ligase activity, crucial for affinity maturation.

The paper shows that an early-life galactose diet in yeast reduces age-related gene dysregulation and senescence markers, suggesting dietary change can mimic caloric restriction benefits without calorie reduction.

This study shows that the Fork Protection Complex reduces DNA damage in regions prone to topological stress but increases genome instability in long replicons by promoting rapid replication.

This study shows that chromosome XII fragments, not ERCs, drive senescence in yeast, despite rDNA copy number increases with age.

The paper investigates how transcriptional activation of the CUP1 gene in budding yeast leads to copy number variation through replication stress and homologous recombination.