Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
Jayashree Chadchankar, Victoria Korneeva Korboukh, Leslie Conway, Heike J. Wobst, Chandler A. Walker, Peter C. Doig, Steve J. Jacobsen, Nicholas J. Brandon, Stephen J. Moss, Qi Wang
The paper investigates the effects of USP14 and UCHL5 inhibition on ubiquitinated protein accumulation in mammalian cells, identifying distinct substrates regulated by each deubiquitinase.
PLoS ONE · Nov 8, 2019Peer-reviewedMolecular Biology