Qi Wang

This study identifies and optimizes SARM1 base-exchange inhibitors but finds they paradoxically activate SARM1 at sub-inhibitory concentrations, leading to neurite degeneration and prompting discontinuation of development.

This study identifies VMN, a metabolite of the pesticide vacor, as a potent SARM1 activator, showing that SARM1 removal rescues vacor-induced neuron and axon death.

The paper investigates the effects of USP14 and UCHL5 inhibition on ubiquitinated protein accumulation in mammalian cells, identifying distinct substrates regulated by each deubiquitinase.