Author

Heike J. Wobst

AstraZeneca (United States)ORCID 0000-0002-9041-3241Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Nicholas J. BrandoniD· 2 shared Stephen J. MossiD· 2 shared Aaron D. GitleriD· 1 shared Alice Flynn Ford· 1 shared Ashkan JavaherianiD· 1 shared Ashmita Baral· 1 shared Bo Lim Lee· 1 shared Bradley Class· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Nicholas J. BrandonORCID

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2 papers

Recent·Most cited

Opposing roles of p38α phosphorylation and arginine methylation in driving TDP-43 proteinopathy.

Mari Aikio, Hana M. Odeh, Heike J. Wobst, Bo Lim Lee, Úna Chan, Jocelyn C. Mauna, Korrie L. Mack, Bradley Class, Thomas A. Ollerhead, Alice Flynn Ford, Edward M. Barbieri, Ryan R. Cupo, Lauren E. Drake, Joshua L. Smalley, Yuan-Ta Lin, , James Shorter

This study identifies opposing roles of p38α phosphorylation and arginine methylation in TDP-43 proteinopathy, showing that phosphorylation promotes aggregation while methylation reduces it.

Cell Reports · Jan 1, 2025Peer-reviewedMolecular Biology

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

Jayashree Chadchankar, Victoria Korneeva Korboukh, Leslie Conway, Heike J. Wobst, Chandler A. Walker, Peter C. Doig, Steve J. Jacobsen, Nicholas J. Brandon, Stephen J. Moss, Qi Wang

The paper investigates the effects of USP14 and UCHL5 inhibition on ubiquitinated protein accumulation in mammalian cells, identifying distinct substrates regulated by each deubiquitinase.

PLoS ONE · Nov 8, 2019Peer-reviewedMolecular Biology