Nicholas J. Brandon

This study identifies opposing roles of p38α phosphorylation and arginine methylation in TDP-43 proteinopathy, showing that phosphorylation promotes aggregation while methylation reduces it.

This paper introduces a new drug-like small molecule series targeting PDI in a multi-protein complex for ALS treatment, showing activity in cellular and animal models.

This study shows estradiol increases local synaptic protein synthesis in both sexes, but mTOR signaling is sex-specifically required for certain synaptic proteins.

This study identifies TNIK-mediated phosphorylation sites on Arc protein, showing their role in regulating Arc's subcellular distribution and self-assembly, linking Arc and TNIK in neuronal function and psychiatric disorders.

The paper identifies transcriptomic differences in human pluripotent stem cells that correlate with retinoic acid response and neural fate bias.

This study shows that KCC2 is essential for the survival of mature neurons but not for their development or structural formation.

This study isolates and characterizes multi-protein complexes containing Kcc2 from brain plasma membranes, identifying novel interactors and phosphorylation sites that may regulate its function.

The paper models the progression of human neural stem cells in vitro, showing they transition through organizer states before committing to cortical excitatory or inhibitory neuronal fates.

The paper identifies KCC2 as a convergence point for ASD/Epi risk genes through proteomic analysis and shows its interaction with FMRP targets and effects on GABAergic inhibition.

The paper uses hiPSC transcriptomics to study neuronal differentiation and maturation across multiple conditions and develops a tool to estimate neuronal maturity.

This study shows that estradiol restores dendritic spine density in a cellular model of schizophrenia and depression by modulating DISC1 function and synaptic protein distribution.

The paper investigates the effects of USP14 and UCHL5 inhibition on ubiquitinated protein accumulation in mammalian cells, identifying distinct substrates regulated by each deubiquitinase.

This study uses MEA assays to show that L-type calcium channel inhibitors affect synchronous firing in hiPSC-derived neuronal networks, suggesting their utility for studying psychiatric risk genes.

This study evaluates biases in small RNA sequencing methods, showing that UMIs improve accuracy and highlighting limitations in current miRNA and isomiR quantification.

This study shows that the cortico-striatal circuit regulates sensorimotor gating through Disc1/Huntingtin-mediated Bdnf transport, with lithium restoring deficits in Disc1-LI mice.

This study shows that Miro ubiquitination is essential for efficient damage-induced mitophagy, with implications for neurological diseases.

The paper identifies 237 genes associated with schizophrenia using RNA sequencing and eQTL analysis, showing enrichment for developmentally regulated synaptic genes.