Chronic Inflammation Induced Immature Neutrophils Drive Immunopathology During Subsequent Inflammatory Events
Alakesh Alakesh, Vinod Kumar Dorai, Ranjitha Guttapadu, Shruthi Ksheera Sagar, Meghna Ravishankar Valakatte, Jayashree Vijaya Raghavan, Monisha Mohandas, S R Kalpana, Nagasuma R Chandra, Siddharth Jhunjhunwala
The paper shows chronic inflammation increases immature neutrophils, which worsen immunopathology during new inflammatory events, and suggests targeting these cells as a therapeutic strategy.
bioRxiv · Apr 24, 2025 · PreprintImmunology