Alakesh Alakesh

This paper develops a hydrogel depot system for long-acting peptide delivery, showing sustained release and improved therapeutic outcomes in rodents.

This paper develops lubricious supramolecular hydrogels to prevent peritendinous adhesions, showing improved recovery and safety in preclinical models.

This paper develops long-acting hydrogel-based depot formulations of semaglutide and tirzepatide that maintain drug levels for over 6 weeks in a rat model, showing similar efficacy to daily injections.

This study develops intranasal sertraline formulations to reduce systemic exposure while maintaining brain delivery, showing comparable brain exposure at half the dose compared to oral administration in mice.

The paper shows chronic inflammation increases immature neutrophils, which worsen immunopathology during new inflammatory events, and suggests targeting these cells as a therapeutic strategy.