Interstrain Recombinants of Human Cytomegalovirus Reveals Complex Genetic Correlates and Epistasis Influencing Glycoprotein Display, Virion Infectivity and Spread Characteristics.
Christopher Peterson, Ian T. Bailey, Jean-Marc Lanchy, Iván Gallego, Brent J. Ryckman
This paper generates recombinant HCMV strains from two distinct parental isolates to study genetic correlates of glycoprotein display, infectivity, and spread characteristics, revealing complex epistasis and non-causal relationships among these phenotypes.
bioRxiv · Sep 22, 2025 · PreprintMicrobiology