Author

Brent J. Ryckman

University of MontanaORCID 0000-0003-2345-3099Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 1 Assay:DNA methylation· 1 Assay:flow cytometry· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Christopher PetersoniD· 2 shared Jean-Marc Lanchy· 2 shared Eric P. SchultziD· 1 shared Florian KleiniD· 1 shared Ian T. BaileyiD· 1 shared Iván GallegoiD· 1 shared Joshua MilleriD· 1 shared Lars Ponsness· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

Christopher PetersonORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 22, 2025

Interstrain Recombinants of Human Cytomegalovirus Reveals Complex Genetic Correlates and Epistasis Influencing Glycoprotein Display, Virion Infectivity and Spread Characteristics.

Christopher Peterson, Ian T. Bailey, Jean-Marc Lanchy…·Brent J. Ryckman

This paper generates recombinant HCMV strains from two distinct parental isolates to study genetic correlates of glycoprotein display, infectivity, and spread characteristics, revealing complex epistasis and non-causal relationships among these phenotypes.

DOI 10.1101/2025.09.22.677782

humanDNA methylation

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MicrobiologybioRxivApr 23, 2025

Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection

Christopher Peterson, Joshua Miller, Brent J. Ryckman, Vitaly V. Ganusov

The paper investigates apparent cooperativity between human CMV virions and shows it affects multiplicity of infection calculations.

DOI 10.7554/elife.108921

humanflow cytometry

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MicrobiologyJournal of VirologyPeer-reviewedApr 9, 2025

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies.

Eric P. Schultz, Lars Ponsness, Jean-Marc Lanchy…·Brent J. Ryckman

This paper develops a cell-cell fusion assay to study HCMV gH/gL/gO receptor engagement and its role in activating gB fusion, showing that PDGFR binding enhances fusion and can be blocked by neutralizing antibodies.

7 citationstop 5%

humanexperimental assay

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