Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies.
Eric P. Schultz, Lars Ponsness, Jean-Marc Lanchy, Matthias Zehner, Florian Klein, Brent J. Ryckman
This paper develops a cell-cell fusion assay to study HCMV gH/gL/gO receptor engagement and its role in activating gB fusion, showing that PDGFR binding enhances fusion and can be blocked by neutralizing antibodies.
Journal of Virology · Apr 9, 2025Peer-reviewedMicrobiology