HCM-associated mutations in MYH6/7 drive pathologic expression of TGF-β1 in cardiomyocytes within weeks of developmental specification
Jeanne Hsieh, Megan A. L. Hall, Mohammad Shameem, Patrick Erñst, Forum D. Kamdar, Bhairab N. Singh, Robert L. Meisel, Brenda M. Ogle
This study shows that HCM-associated mutations in MYH6/7 lead to increased TGF-β1 expression in cardiomyocytes, driving fibroblast activation and ECM changes within weeks of developmental specification.
bioRxiv · Aug 8, 2024 · PreprintBioengineering