Bhairab N. Singh

Cryoaerosolization Enables Scalable Vitrification-Based Cell Cryopreservation

This paper introduces a cryoaerosolization method for scalable vitrification-based cell cryopreservation, achieving high cooling and warming rates with high throughput and cell viability.

HCM-associated mutations in MYH6/7 drive pathologic expression of TGF-β1 in cardiomyocytes within weeks of developmental specification

This study shows that HCM-associated mutations in MYH6/7 lead to increased TGF-β1 expression in cardiomyocytes, driving fibroblast activation and ECM changes within weeks of developmental specification.

The HH-GLI2-CKS1B network regulates the proliferation-to-maturation transition of human cardiomyocytes

This study identifies the HH-GLI2-CKS1B network as a regulator of the proliferation-to-maturation transition in human cardiomyocytes, with implications for cardiac regeneration.

A novel algorithm for the collective integration of single cell RNA-seq during embryogenesis

This paper introduces a novel algorithm to integrate heterogeneous temporal scRNA-seq datasets and reconstruct lineage trajectories, identifying Ebf1 as a key transcription factor for mouse endothelial development.