BioengineeringbioRxivPreprint
HCM-associated mutations in MYH6/7 drive pathologic expression of TGF-β1 in cardiomyocytes within weeks of developmental specification
Jeanne Hsieh, Megan A. L. Hall, Mohammad Shameem…·Brenda M. Ogle
This study shows that HCM-associated mutations in MYH6/7 lead to increased TGF-β1 expression in cardiomyocytes, driving fibroblast activation and ECM changes within weeks of developmental specification.
DOI 10.1101/2024.08.08.606705