Brenda M. Ogle

This study identifies a sexually dimorphic NLRP3 signaling pathway in right ventricular failure, showing estrogen receptor α mediates protection against NLRP3-induced contractile dysfunction in cardiomyocytes.

The paper generates hiPSC-CM from male and female donors and finds sex dimorphism in calcium handling and gene expression without hormone exposure.

The paper investigates gene regulation and cell-cell communication changes in murine stem cell-cardiomyocyte hybrids using single-cell RNA sequencing data.

This study shows that HCM-associated mutations in MYH6/7 lead to increased TGF-β1 expression in cardiomyocytes, driving fibroblast activation and ECM changes within weeks of developmental specification.

This study identifies the HH-GLI2-CKS1B network as a regulator of the proliferation-to-maturation transition in human cardiomyocytes, with implications for cardiac regeneration.