A rapid, genetically-tractable human iPSC-derived model for studying tissue-resident macrophage biology in Alzheimer's and other diseases
Hyo Lee, Grace B. Peppler, Michael D.E. Sewell, Alexandra E. Münch, Anna Podlesny‐Drabiniok, Jeanne J Kim, Joshua Orrick, Edoardo M. Marcora, Alison Goate
This paper develops a simplified protocol to generate human iPSC-derived macrophage-like cells (iMacs) that exhibit enhanced phagocytic and TREM2-related functions, making them a useful model for studying macrophage biology in Alzheimer's and other diseases.
bioRxiv · Oct 12, 2026 · PreprintNeuroscience