Author

Hyo Lee

Brigham and Women's HospitalORCID 0000-0002-4741-0707Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 5 Organism:human· 5 Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Philip L. De JageriD· 4 shared Richard V. PearseiD· 4 shared Tracy L. Young‐PearseiD· 4 shared Vilas MenoniD· 4 shared David Alan BennettiD· 3 shared Nicholas T. SeyfriediD· 3 shared Cheryl PaniD· 2 shared Duc Minh DuongiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Philip L. De JagerORCID

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5 papers

Recent·Most cited

A rapid, genetically-tractable human iPSC-derived model for studying tissue-resident macrophage biology in Alzheimer's and other diseases

Hyo Lee, Grace B. Peppler, Michael D.E. Sewell, Alexandra E. Münch, Anna Podlesny‐Drabiniok, Jeanne J Kim, Joshua Orrick, Edoardo M. Marcora, Alison Goate

This paper develops a simplified protocol to generate human iPSC-derived macrophage-like cells (iMacs) that exhibit enhanced phagocytic and TREM2-related functions, making them a useful model for studying macrophage biology in Alzheimer's and other diseases.

bioRxiv · Oct 12, 2026 · PreprintNeuroscience

Contributions of genetic variation in astrocytes to cell and molecular mechanisms of risk and resilience to late onset Alzheimer's disease

Hyo Lee, Richard V. Pearse, Alexandra M Lish, Cheryl Pan, Zachary M. Augur, Gizem Terzioğlu, Pallavi Gaur, Meichen Liao, Masashi Fujita, Earvin S. Tio, Duc Minh Duong, Daniel Felsky, Nicholas T. Seyfried, Vilas Menon, David A. Bennett, , Tracy L. Young‐Pearse

The paper uses iPSC-derived astrocytes to study genetic risk factors for Alzheimer's disease, finding concordant molecular changes in both astrocytes and brain tissue.

Glia · Feb 3, 2025Peer-reviewedNeuroscience

INPP5D/SHIP1 regulates inflammasome activation in human microglia

Vicky Chou, Seeley B. Fancher, Richard V. Pearse, Hyo Lee, Matti Lam, Nicholas T. Seyfried, David Alan Bennett, Philip L. De Jager, Vilas Menon, Tracy L. Young‐Pearse

This study shows that INPP5D/SHIP1 regulates inflammasome activation in human microglia, with reduced INPP5D leading to increased IL-1β and IL-18 secretion.

bioRxiv · Feb 25, 2023 · PreprintNeuroscience

Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1

Hyo Lee, Aimee J. Aylward, Richard V. Pearse, Yi‐Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc Minh Duong, Nicholas T. Seyfried, David Alan Bennett, Hans‐Ulrich Klein, Philip L. De Jager, , Tracy L. Young‐Pearse

This study shows that SORL1 loss reduces APOE levels specifically in neurons and astrocytes, linking SORL1 and APOE to Alzheimer's disease risk through distinct pathways.

bioRxiv · Feb 25, 2023 · PreprintNeuroscience

Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex

Masashi Fujita, Zongmei Gao, Lu Zeng, Cristin Aubin, Charles C. White, Bernard Ng, Gilad Sahar Green, Orit Rozenblatt–Rosen, Devan Phillips, Liat Amir-Zilberstein, Hyo Lee, Richard V. Pearse, Atlas Khan, Badri Narayan Vardarajan, Krzysztof Kiryluk, , Philip L. De Jager

The paper identifies cell-type and cell-subtype specific eQTLs in aging human cortex, revealing variant effects on gene expression and disease associations.

bioRxiv · Nov 7, 2022 · PreprintGenomics