Author

Joshua Orrick

Icahn School of Medicine at Mount SinaiORCID 0009-0009-4083-6172Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Organism:Drosophila· 1

Frequent Co-Authors

Alison GoateiD· 3 shared Chiara PediconeiD· 2 shared Alexandra E. MünchiD· 1 shared Anna Podlesny‐DrabiniokiD· 1 shared Celeste M M. KarchiD· 1 shared Chihiro SatoiD· 1 shared Cindy V. LyiD· 1 shared Derian A. Pugh· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Alison GoateORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 12, 2026

A rapid, genetically-tractable human iPSC-derived model for studying tissue-resident macrophage biology in Alzheimer's and other diseases

Hyo Lee, Grace B. Peppler, Michael D.E. Sewell…·Alison Goate

This paper develops a simplified protocol to generate human iPSC-derived macrophage-like cells (iMacs) that exhibit enhanced phagocytic and TREM2-related functions, making them a useful model for studying macrophage biology in Alzheimer's and other diseases.

DOI 10.64898/2026.10.08.757653

humanbulk RNA-seq

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NeuroscienceAnnals of NeurologyPeer-reviewedJul 19, 2026

Distribution of big tau isoforms in the human central and peripheral nervous system

Rama K. Koppisetti, Nicolas R. Barthélemy, Kanta Horie…·Soumya Mukherjee

The paper characterizes big tau isoforms in human nervous system tissues and CSF, finding they are enriched in the peripheral nervous system and largely unaffected by neurodegenerative disease.

7 citationstop 1%

humanproteomics

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NeurosciencebioRxivPreprintNov 29, 2025

Alternative Anastrozole Target CYP4V2 Impairs Neurons in Preclinical Models of Inherited Tauopathy

Chiara Pedicone, Sarah A. Weitzman, Joshua Orrick…·Masahiro Sonoshita

This study identifies anastrozole's off-target CYP4V2 as a neuroprotective factor in tauopathy models by reducing Tau phosphorylation and oxidative stress.

DOI 10.1101/2025.11.29.689498

Drosophilahuman

𝕏 PostBluesky