Author

Anna Podlesny‐Drabiniok

Icahn School of Medicine at Mount SinaiORCID 0000-0001-5009-2263Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Alison GoateiD· 3 shared Edoardo M. MarcoraiD· 3 shared Yiyuan LiuiD· 2 shared Alexandra E. MünchiD· 1 shared Carmen Romero‐MolinaiD· 1 shared Chiara GiannarelliiD· 1 shared Gloriia NovikovaiD· 1 shared Grace B. PeppleriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersNeuroscience

Alison GoateORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 12, 2026

A rapid, genetically-tractable human iPSC-derived model for studying tissue-resident macrophage biology in Alzheimer's and other diseases

Hyo Lee, Grace B. Peppler, Michael D.E. Sewell…·Alison Goate

This paper develops a simplified protocol to generate human iPSC-derived macrophage-like cells (iMacs) that exhibit enhanced phagocytic and TREM2-related functions, making them a useful model for studying macrophage biology in Alzheimer's and other diseases.

DOI 10.64898/2026.10.08.757653

humanbulk RNA-seq

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ImmunologyCell ReportsPeer-reviewedJun 25, 2025

Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro

Anna Podlesny‐Drabiniok, Carmen Romero‐Molina, Tulsi Patel…·Alison Goate

This study reprograms human macrophages in vitro using cytokines to mimic Alzheimer's disease-relevant phenotypes, showing transcriptomic and functional changes similar to disease-associated microglia.

7 citations

humanbulk RNA-seq

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NeurosciencebioRxivPreprintFeb 13, 2023

BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer's disease and other disorders of lipid-rich tissues

Anna Podlesny‐Drabiniok, Gloriia Novikova, Yiyuan Liu…·Alison Goate

This study identifies BHLHE40/41 as key regulators of macrophage/microglia responses in Alzheimer's disease and other lipid-rich tissue disorders through sc/nRNA-seq analysis and functional validation.

6 citations

humanmouse

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