Structure, dynamics and evolution of the Candida albicans multi-drug resistance ABC transporter CDR1
Jeeeun Shin, Ruitao Jin, Barnabas Gall, Chacko Jobichen, Colin J. Jackson, Melanie Rug, Ben Corry, Joseph Brock
This study presents high-resolution structures of C. albicans Cdr1 in multiple states and uses simulations and evolutionary analysis to elucidate its transport mechanism and drug resistance.
bioRxiv · Oct 28, 2024 · PreprintMicrobiology