Author

Melanie Rug

Australian National UniversityORCID 0000-0002-4687-9677Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adrian F. LoiD· 1 shared Alexandra J. SpenceriD· 1 shared Andrea DoiD· 1 shared Barnabas GalliD· 1 shared Ben CorryiD· 1 shared Chacko JobicheniD· 1 shared Colin J. JacksoniD· 1 shared Daniel Fernandez‐RuiziD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Adrian F. LoORCID

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2 papers

Recent·Most cited

B cells targeting parasites capture spatially linked antigens to secure T cell help

Xin Gao, Hayley A. McNamara, Jiwon Lee, Adrian F. Lo, Deepyan Chatterjee, Dominik Spensberger, Daniel Fernandez‐Ruiz, Kevin Walz, Ke Wang, Hannah G. Kelly, Kai G. Pohl, Patricia E. Carreira, Andrea Do, Le Xiong, Lynette Beattie, , Ian Andrew Cockburn

The paper investigates how B cells targeting Plasmodium parasites capture spatially linked antigens to receive T cell help, showing that B cells can obtain help from T cells specific to surface antigens, not just the same protein.

Science Immunology · Nov 7, 2025Peer-reviewedImmunology

Structure, dynamics and evolution of the Candida albicans multi-drug resistance ABC transporter CDR1

Jeeeun Shin, Ruitao Jin, Barnabas Gall, Chacko Jobichen, Colin J. Jackson, Melanie Rug, Ben Corry, Joseph Brock

This study presents high-resolution structures of C. albicans Cdr1 in multiple states and uses simulations and evolutionary analysis to elucidate its transport mechanism and drug resistance.

bioRxiv · Oct 28, 2024 · PreprintMicrobiology