PDX1 directs a core developmentally and evolutionarily conserved gene program in the pancreatic islet
Xiaodun Yang, Jeffrey C. Raum, Junil Kim, Reynold Yu, Juxiang Yang, Gabriella Rice, Changhong Li, Kyoung‐Jae Won, Doris A. Stoffers, Diana E. Stanescu
The paper identifies a core set of developmentally and evolutionarily conserved PDX1-bound genes in mouse and human pancreas development, showing stable PDX1 binding across ages with context-dependent regulatory roles.
bioRxiv · Feb 28, 2021 · PreprintDevelopmental Biology