Diana E. Stanescu

The paper shows that decreased KATP channel surface density in early postnatal rat beta-cells lowers the glucose threshold for insulin secretion, which normalizes by postnatal day 14.

This study shows that early postnatal activation of the HIF1A pathway in rats causes hyperinsulinism and reduced β-cell proliferation, potentially increasing diabetes risk.

The paper identifies a core set of developmentally and evolutionarily conserved PDX1-bound genes in mouse and human pancreas development, showing stable PDX1 binding across ages with context-dependent regulatory roles.