A Novel Glia-immune humanized mouse model for investigation of HIV CNS infection and neuroinflammation.
Shallu Tomer, Lin Pan, Jeffrey S. Harding, Valerie K. Rezek, Mitchell C. Krawczyk, Ethan Cook, Nandita Kedia, Li Wang, Jonathan Le, Christopher Platt, Heather A. Martin, Erik Gramajo, Xiang Li, Yewen Zhang, Ariel S. Peng, , Anjie Zhen
This paper develops a humanized mouse model with human glia and immune cells to study HIV CNS infection and neuroinflammation, showing HIV replication and synapse loss in the brain.
bioRxiv · Mar 5, 2025 · PreprintImmunology