Lin Pan

This study shows that prenatal lead exposure biases neural cell fate in human brain development by increasing neurons and reducing astrocytes through epigenetic changes.

This paper develops a humanized mouse model with human glia and immune cells to study HIV CNS infection and neuroinflammation, showing HIV replication and synapse loss in the brain.

The paper investigates how microglia and the extracellular matrix influence cognitive aging by analyzing ECM composition, microglial interactions, and their relationship with synapses and behavior.

This study identifies transcriptomic signatures of human astrocytes across age, sex, and disease states, revealing changes in synaptic function, ionic homeostasis, and tumor microenvironment interactions.

The paper compares gene expression and stress responses in human and mouse astrocytes, finding conserved and divergent features that may explain differences in disease models.