Author

Jonathan Le

University of California, Los Angeles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Abbas H. Rizvi· 1 shared Anjie ZheniD· 1 shared Ariel S. Peng· 1 shared Christopher Platt· 1 shared Drew N TrygstadiD· 1 shared Elena K. KandroriD· 1 shared Erik Gramajo· 1 shared Ethan Cook· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Abbas H. Rizvi

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Opposing Experiences Shape Parvalbumin Interneuron Plasticity through Distinct Molecular Programs

Yu Guo, Yu Gao, Sara Knaack, Minjie Shen, Zhiyan Xu, Jiyoun Lee, Yajie Zhang, Paofue Yang, Sabrina X. Huang, Ezra D. Jarzembowski, Drew N Trygstad, Jensen T Weik, Jonathan Le, Keegan A. Schoeller, Elena K. Kandror, , Xinyu Zhao

The paper shows that chronic stress and voluntary running induce distinct molecular programs in parvalbumin interneurons, with stress increasing KAT6A and H3K23 acetylation in the frontal cortex.

bioRxiv · Sep 3, 2026 · PreprintNeuroscience

A Novel Glia-immune humanized mouse model for investigation of HIV CNS infection and neuroinflammation.

Shallu Tomer, Lin Pan, Jeffrey S. Harding, Valerie K. Rezek, Mitchell C. Krawczyk, Ethan Cook, Nandita Kedia, Li Wang, Jonathan Le, Christopher Platt, Heather A. Martin, Erik Gramajo, Xiang Li, Yewen Zhang, Ariel S. Peng, , Anjie Zhen

This paper develops a humanized mouse model with human glia and immune cells to study HIV CNS infection and neuroinflammation, showing HIV replication and synapse loss in the brain.

bioRxiv · Mar 5, 2025 · PreprintImmunology