Anjie Zhen

This paper demonstrates that combining HIV-specific CAR T cells with rapamycin and latency reversing agents can reduce immune exhaustion and effectively target HIV-infected cells.

This paper develops an HSPC-based gene therapy with anti-HIV-1 genes and a safety kill switch, showing significant viral load reduction in huBLT mice.

This paper develops a humanized mouse model with human glia and immune cells to study HIV CNS infection and neuroinflammation, showing HIV replication and synapse loss in the brain.

This study shows that rapamycin enhances CAR-T cell function and reduces HIV viral rebound and reservoir in HIV-infected humanized mice.