Cancer BiologybioRxivPreprint
Mechano-signaling of prostate tumor initiating cells facilitates their tropism to stiff metastatic niche
Lanpeng Chen, Gangyin Zhao, Marta De Menna…·Ewa B. Snaar-Jagalska
The paper shows that mechanotransduction via TAZ and cytoskeletal tension promotes prostate cancer stem cell metastasis and identifies a YAP/TAZ inhibitor as a potential therapeutic target.
DOI 10.1101/2023.08.28.553410