Marianna Kruithof‐de Julio

Spatial single-cell proteomics defines multicellular niches in the primary prostate cancer microenvironment

The paper uses spatial single-cell proteomics to map multicellular niches in primary prostate cancer, identifying prognostic cell types and niches beyond Gleason grading.

Iron Metabolism as a Therapeutic Vulnerability in Stem Cell-Like Castration-Resistant Prostate Cancer

This study identifies iron metabolism as a therapeutic target in stem cell-like castration-resistant prostate cancer by showing that inhibiting NRF2 induces ferroptosis in CD44hi cells.

Optimised dissociation and multimodal profiling of prostate cancer stroma reveal fibromuscular cell heterogeneity with clinical correlates

The paper optimizes dissociation protocols and uses multimodal profiling to characterize fibromuscular stromal heterogeneity in prostate cancer with clinical relevance.

A Human Alveolus-on-Chip Recapitulates SARS-CoV-2-mediated Lung Injury in an Organ-relevant Context for Pre-clinical Applications

This paper develops a Lung-on-Chip model to study SARS-CoV-2 infection in the alveolar barrier and demonstrates its utility for drug testing.

Functional identification of cis-regulatory long noncoding RNAs at controlled false-discovery rates

The paper introduces TransCistor, a framework to identify cis-regulatory lncRNAs with controlled false discovery rates, finding that only a minority of lncRNAs are cis-acting, primarily as activators.

Multiplexed tumor profiling with generative AI accelerates histopathology workflows and improves clinical predictions

This paper introduces VirtualMultiplexer, a generative AI tool that translates H&E images to IHC images, improving clinical predictions and accelerating histopathology workflows.

Tumour mutations in long noncoding RNAs enhance cell fitness

The paper identifies mutated long noncoding RNAs (lncRNAs) as contributors to tumour cell fitness through experimental validation of their oncogenic effects.