Sp1 mechanotransduction regulates breast cancer cell invasion in response to multiple tumor-mimicking extracellular matrix cues
Abhishek Sharma, Rowan F. Steger, Jen M. Li, Jane A. Baude, Kellie A. Heom, Siddharth S. Dey, Ryan S. Stowers
This study shows that Sp1 mechanotransduction enhances breast cancer cell invasion in response to combined ECM cues like stiffness, stress relaxation, and collagen density.
bioRxiv · Mar 18, 2025 · PreprintBioengineering