Ryan S. Stowers

Glycoconjugates tune the viscoelastic signature of mammary tumor progression

This study shows that breast tumors are more viscoelastic than normal tissue, driven by glycoconjugates, and that increased viscoelasticity promotes malignant behavior in epithelial cells.

Matrix viscoelasticity regulates dermal fibroblast activation in a three-dimensional fibrillar microenvironment

This study shows that fibroblast activation is influenced by matrix viscoelasticity in 3D fibrillar microenvironments, with slow stress relaxation and stiffness promoting activation and ECM remodeling.

Matrix stiffness and stress relaxation regulate osteogenesis through histone demethylases KDM4B and KDM6B

This study shows that matrix stiffness and stress relaxation influence osteogenesis by regulating histone demethylases KDM4B and KDM6B through mechanotransduction signaling.

Matrix stiffness and stress relaxation regulate matrix-bound nanovesicle release from alginate hydrogels

This study shows that alginate hydrogel stiffness and stress relaxation rates control the release of matrix-bound nanovesicles (MBVs) over time, offering a method to improve their therapeutic delivery.

Extracellular matrix viscoelasticity regulates mammary branching morphogenesis

This study shows that slow stress-relaxing matrices promote greater mammary branching morphogenesis compared to fast stress-relaxing matrices.

Engineered basement membrane mimetic hydrogels to study mammary epithelial morphogenesis and invasion

This paper develops an engineered basement membrane hydrogel to study mammary epithelial morphogenesis and invasion, finding that specific mechanical and biochemical properties drive invasive behavior.

Sp1 mechanotransduction regulates breast cancer cell invasion in response to multiple tumor-mimicking extracellular matrix cues

This study shows that Sp1 mechanotransduction enhances breast cancer cell invasion in response to combined ECM cues like stiffness, stress relaxation, and collagen density.

Stress relaxation rates of myocardium from failing and non-failing hearts

This study measures stress relaxation in myocardial tissue from failing and non-failing hearts, finding differences linked to fibrosis and fat accumulation.