Jane A. Baude

Glycoconjugates tune the viscoelastic signature of mammary tumor progression

This study shows that breast tumors are more viscoelastic than normal tissue, driven by glycoconjugates, and that increased viscoelasticity promotes malignant behavior in epithelial cells.

Matrix stiffness and stress relaxation regulate matrix-bound nanovesicle release from alginate hydrogels

This study shows that alginate hydrogel stiffness and stress relaxation rates control the release of matrix-bound nanovesicles (MBVs) over time, offering a method to improve their therapeutic delivery.

Engineered basement membrane mimetic hydrogels to study mammary epithelial morphogenesis and invasion

This paper develops an engineered basement membrane hydrogel to study mammary epithelial morphogenesis and invasion, finding that specific mechanical and biochemical properties drive invasive behavior.

Sp1 mechanotransduction regulates breast cancer cell invasion in response to multiple tumor-mimicking extracellular matrix cues

This study shows that Sp1 mechanotransduction enhances breast cancer cell invasion in response to combined ECM cues like stiffness, stress relaxation, and collagen density.