Kellie A. Heom

scSTAMP-seq enables spatially resolved single-cell transcriptomics and epigenomics by using photolabile oligonucleotides and light gradients to capture cell positions before sequencing.

The paper introduces scMHT-seq, a single-cell method to profile 5mC, 5hmC, and transcriptomes, revealing DNA methylation erasure mechanisms in human primordial germ cell maturation.

This study shows that Sp1 mechanotransduction enhances breast cancer cell invasion in response to combined ECM cues like stiffness, stress relaxation, and collagen density.

EMBR-seq+ efficiently depletes rRNA in diverse bacterial species and co-cultures, enabling accurate transcriptome analysis of non-model microbial systems.

The paper introduces EMBR-seq, a method for efficient and cost-effective bacterial mRNA sequencing by depleting rRNA, enabling deeper transcriptome analysis from low input samples.