Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: implications for nociception
Michaela Dvořáková, Taryn Bosquez-Berger, Jenna Billingsley, Natalia Murataeva, Taylor J. Woodward, Emma Leishman, Anaëlle Zimmowitch, Anne Gibson, Jim Wager‐Miller, Ruyi Cai, Shangxuan Cai, Tim Ware, Ku‐Lung Hsu, Yulong Li, Heather B. Bradshaw, , Alex J. Straiker
The paper shows acetaminophen inhibits DAGLα, reducing 2-arachidonoyl glycerol production and suggesting a novel antinociceptive mechanism involving DAGLα/CB1 circuits.
Cell Reports Medicine · May 16, 2025Peer-reviewedNeuroscience