Cellular senescence is associated with age-related loss of liver zonation and hepatocyte function
Linshan Laux, Alisha Aristel, Syed Ali, Kathryn Lande, Meiyi Li, K. Garrett Evensen, Aaron P. Havas, Zhen Miao, Jane Zhang, Sam Peters, Jiayi Hu, Luise A. Angelini, Maggie Klaers, Jennie Brocksome, Adam Lewis, , Laura J. Niedernhofer
This study shows that cellular senescence disrupts liver zonation and hepatocyte function with age by altering gene expression and cell signaling.
bioRxiv · Aug 10, 2026 · PreprintCell Biology