Linshan Laux

The paper identifies age-associated differential transcript usage in mouse tissues, showing regulatory isoform switching with tissue-specific structural consequences.

This study shows that targeting CCND1-CDK6 reduces DNA damage, inflammation, and age-related decline in mice by suppressing SASP and ISG expression.

This study shows that cellular senescence disrupts liver zonation and hepatocyte function with age by altering gene expression and cell signaling.

This study shows that ATGL-catalyzed lipid catabolism enhances DNA double-strand break repair, reducing genomic instability and aging-related damage.

This study shows cyclin D1 regulates hepatic gene networks and metabolic responses to feeding, with non-cell cycle roles in aging, MASLD, and C. elegans overnutrition.

CoPro identifies spatially coordinated gene expression programs across tissues, revealing distinct cellular states and their interactions in colon, brain, liver, and kidney.