April E. Williams

This study identifies age-associated repression of HNF4α as a driver of liver metabolic dysfunction and shows that restoring HNF4α can reverse some age-related liver defects.

The paper shows that escaping replicative crisis and achieving immortality precedes complex genome evolution in cancer cells.

This study shows that targeting CCND1-CDK6 reduces DNA damage, inflammation, and age-related decline in mice by suppressing SASP and ISG expression.

This study shows that cellular senescence disrupts liver zonation and hepatocyte function with age by altering gene expression and cell signaling.

This study uses patient-derived organoids to identify CFTR modulators as a therapeutic strategy for chronic pancreatitis.

The paper identifies Med14 phosphorylation as essential for sustained GLP-1 agonist-induced gene regulation in beta cells.

This study identifies a valine-to-leucine mutation in AP2-G that disrupts DNA binding and sexual differentiation in Plasmodium falciparum, revealing GDV1's role in ap2-g activation.

The paper identifies YAP1 as a non-canonical effector of RA signaling essential for atrial lineage commitment in cardiac progenitor cells.

PCBS is an R package that provides fast and accurate analysis of whole-genome bisulfite sequencing data, offering improved accuracy and flexibility over existing tools.

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.

The paper genotypes over 4,000 Sprague Dawley rats to characterize genetic diversity and performs GWAS on Pavlovian conditioned approach behavior, identifying 46 significant loci.

The paper identifies genetic variants responsible for gene expression differences between C57BL/6 and C57BL/10 mouse substrains.

This study shows that activating astroglia in the lateral habenula prevents the antidepressant effect of bright light stimulation in a mouse model resistant to antidepressants.

This study analyzes the transcriptomes of four major tissues in adult C. elegans to identify tissue-specific genes, isoforms, and regulatory patterns, providing a resource for understanding adult multicellular biology.