Author

Luise A. Angelini

University of Minnesota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Laura J. NiedernhoferiD· 4 shared Paul D. RobbinsiD· 4 shared Abdalla D. MohamediD· 3 shared Allancer NunesiD· 3 shared Brian Hughes· 3 shared Carolina Soto-PalmaiD· 3 shared Lei Justan ZhangiD· 3 shared Osama ElsallabiiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCell Biology

Laura J. NiedernhoferORCID

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4 papers

Recent·Most cited

Cellular senescence is associated with age-related loss of liver zonation and hepatocyte function

Linshan Laux, Alisha Aristel, Syed Ali, Kathryn Lande, Meiyi Li, K. Garrett Evensen, Aaron P. Havas, Zhen Miao, Jane Zhang, Sam Peters, Jiayi Hu, Luise A. Angelini, Maggie Klaers, Jennie Brocksome, Adam Lewis, , Laura J. Niedernhofer

This study shows that cellular senescence disrupts liver zonation and hepatocyte function with age by altering gene expression and cell signaling.

bioRxiv · Aug 10, 2026 · PreprintCell Biology

Identification of lipid senolytics targeting senescent cells through ferroptosis induction

Lei Justan Zhang, Rahagir Salekeen, Carolina Soto-Palma, Osama Elsallabi, Hongping Ye, Brian Hughes, Borui Zhang, Allancer Nunes, Kyoo-a Lee, Wandi Xu, Abdalla D. Mohamed, Ellie Piepgras, Sara J. McGowan, Luise A. Angelini, Ryan D. O'Kelly, , Paul D. Robbins

This study identifies lipid senolytics that kill senescent cells via ferroptosis, extending healthspan in mice by targeting ACSL4, LPCAT3, and ALOX15.

Cell Press Blue · Feb 26, 2026Peer-reviewedCell Biology

Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair

Lei Justan Zhang, Osama Elsallabi, Carolina Soto-Palma, Josh Bartz, Rahagir Salekeen, Allancer Nunes, Wandi Xu, Kyooa Lee, Brian Hughes, Borui Zhang, Abdalla D. Mohamed, Sara J. McGowan, Luise A. Angelini, Ryan D. O'Kelly, Seyed Ali Biashad, , Paul D. Robbins

This study identifies fucoidans as senotherapeutics that enhance SIRT6-dependent DNA repair and reduce senescence in aged mice.

bioRxiv · Apr 27, 2025 · PreprintCell Biology

Development of novel flavonoid senolytics through phenotypic drug screening and drug design

Lei Justan Zhang, Rahagir Salekeen, Carolina Soto-Palma, Yuanjun He, Osama Elsallabi, Brian Hughes, Allancer Nunes, Wentao Xu, Borui Zhang, Abdalla D. Mohamed, Sara J. McGowan, Luise A. Angelini, Ryan D. O'Kelly, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins

This study develops two novel flavonoid senolytics through phenotypic drug screening and design, showing enhanced senolytic activity and healthspan extension in a mouse model.

bioRxiv · Oct 27, 2024 · PreprintCell Biology