Laura J. Niedernhofer

Identification of an Endothelial Senotype Predicted by Ion Channel Expression in Aged Murine Perigonadal Adipose Tissue

The paper identifies age-dependent senescent endothelial cells in adipose tissue using snRNA-Seq and finds ion channel genes as predictive biomarkers.

Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline

This study shows that targeting CCND1-CDK6 reduces DNA damage, inflammation, and age-related decline in mice by suppressing SASP and ISG expression.

Cellular senescence is associated with age-related loss of liver zonation and hepatocyte function

This study shows that cellular senescence disrupts liver zonation and hepatocyte function with age by altering gene expression and cell signaling.

Cyclin D1 regulates the hepatic response to feeding: Evidence for non-cell cycle roles in the liver

This study shows cyclin D1 regulates hepatic gene networks and metabolic responses to feeding, with non-cell cycle roles in aging, MASLD, and C. elegans overnutrition.

Dissecting the coordinated progression of cell states in spatial transcriptomics with CoPro

CoPro identifies spatially coordinated gene expression programs across tissues, revealing distinct cellular states and their interactions in colon, brain, liver, and kidney.

Age-associated increases in inter-individual gene expression variability across human tissues

The paper identifies age-related increases in inter-individual gene expression variability using the Gene Stability Score in GTEx data, showing distinct biological impacts and non-random network architecture.

STEVE: Single-cell Transcriptomics Expression Visualization and Evaluation

STEVE evaluates cell-type annotation robustness in scRNA-seq datasets through subsampling, novel cell detection, and benchmarking against ground-truth labels.

Identification of lipid senolytics targeting senescent cells through ferroptosis induction

This study identifies lipid senolytics that kill senescent cells via ferroptosis, extending healthspan in mice by targeting ACSL4, LPCAT3, and ALOX15.

Comprehensive healthspan assessments and influence of sex as a biological variable in aging rats

This study presents a longitudinal assessment of age-related changes in Brown-Norway rat physiology and histopathology at 6, 17, and 27 months of age to provide healthspan parameters for aging research.

Uniquely high spontaneous mutational load in blood cells of XP-C patients

The paper identifies a high spontaneous mutational load in PBMCs of XP-C patients, linked to specific mutation signatures and replication-dependent mutagenesis.

Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair

This study identifies fucoidans as senotherapeutics that enhance SIRT6-dependent DNA repair and reduce senescence in aged mice.

Clonal dynamics and somatic evolution of haematopoiesis in mouse

This study examines clonal dynamics and somatic evolution in mouse haematopoiesis, finding that stem cells accrue mutations at a rate similar to human progenitors and exhibit distinct age-related patterns.

Development of novel flavonoid senolytics through phenotypic drug screening and drug design

This study develops two novel flavonoid senolytics through phenotypic drug screening and design, showing enhanced senolytic activity and healthspan extension in a mouse model.

Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.

Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.