Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks
Matthew A. Schaich, Tyler Weaver, Jennifer A Rakowski, Vera Y. Roginskaya, Liam P. Leary, Aafke A. van den Berg, Janet Iwasa, Bret Freudenthal, Bennett Van Houten
This study investigates how PARP1 binds to DNA breaks and chromatin, revealing that nucleosome unwrapping and allostery influence its affinity and binding dynamics.
Nature Communications · Dec 8, 2025Peer-reviewedBiophysics