Tyler Weaver

Structure of Blm10:13S proteasome intermediate reveals parallel assembly pathways for the proteasome core particle

The paper presents cryo-EM structures of a Blm10:13S proteasome intermediate, revealing parallel assembly pathways for the proteasome core particle involving Blm10 and Pba1/Pba2.

Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα

This study investigates how DNA Ligase IIIα ligates nicks in nucleosomes using biochemical assays, molecular dynamics, and cryo-EM, revealing position-dependent efficiency and structural constraints.

Structural basis of end processing in the nucleosome by polynucleotide kinase phosphatase

This study defines the structural basis of how PNKP processes non-ligatable SSBs in the nucleosome using cryo-EM and biochemical assays.

A Dynamic Search Mechanism Enables APE1 to Identify AP-Sites in DNA

This study reveals how APE1 uses a dynamic search mechanism combining 1D and 3D diffusion to efficiently locate and repair AP-sites in DNA.

Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks

This study investigates how PARP1 binds to DNA breaks and chromatin, revealing that nucleosome unwrapping and allostery influence its affinity and binding dynamics.

Fork Reversal Safeguards Epigenetic Inheritance during DNA Replication Under Stress

This study shows that replication fork reversal is essential for maintaining epigenetic inheritance under replication stress by preventing nucleosome loss and ensuring histone transfer.

Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β

This study determines the structural and kinetic mechanism of DNA Polymerase β processing 1-nt gaps in the nucleosome during DNA repair.

Hierarchical determinants of the oxidation-induced mutational landscape in human cells.

This study identifies factors influencing 8-oxoG-induced mutagenesis in human cells, revealing a hierarchical DNA repair network and chromatin structure effects on mutation patterns.

REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR

This paper identifies UNC7040 as a potent CBX8-specific positive allosteric modulator that disrupts PRC1 function and reduces cancer cell proliferation.