Author

Liam P. Leary

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Bennett Van HouteniD· 2 shared Matthew A. SchaichiD· 2 shared Aafke A. van den BergiD· 1 shared Andrew Rhiner· 1 shared Ayesha RahmaniD· 1 shared Bret FreudenthaliD· 1 shared Dmitri V. FilippoviD· 1 shared Elizabeth G. Blade· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Bennett Van HoutenORCID

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2 papers

Recent·Most cited

PARP1 recruits SPRTN to DNA-protein crosslinks through a conserved poly-ADP-ribose binding domain.

Katelyn Hurley, Liam P. Leary, Martin Garcia, Ayesha Rahman, Matthew A. Schaich, Max S. Kloet, Frederick Kumi-Ansah, Elizabeth G. Blade, Qiang Liu, Andrew Rhiner, Megan K. Le, Quincee Simonson, Dmitri V. Filippov, Gerbrand J. van der Heden van Noort, Jason S. McLellan, , Jaime López-Mosqueda

This study identifies PARP1's role in recruiting SPRTN to DPCs via PARylation, revealing a mechanism for DPC repair and degradation.

bioRxiv · Jan 9, 2026 · PreprintMolecular Biology

Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks

Matthew A. Schaich, Tyler Weaver, Jennifer A Rakowski, Vera Y. Roginskaya, Liam P. Leary, Aafke A. van den Berg, Janet Iwasa, Bret Freudenthal, Bennett Van Houten

This study investigates how PARP1 binds to DNA breaks and chromatin, revealing that nucleosome unwrapping and allostery influence its affinity and binding dynamics.

Nature Communications · Dec 8, 2025Peer-reviewedBiophysics